Endocrine Abstracts

A 33-year-old woman was seen in the Endocrinology Clinic in May 2023 due to abnormal thyroid function tests with normal TSH and persistently elevated free T4 and free T3. She had been under investigation for tiredness, palpitations, and weight gain. The differential diagnosis was TSH-secreting tumour or thyroid hormone resistance. Her bloods were sent to Basingstoke Hospital and assay interference by heterophilic antibodies was excluded. She underwent a thyroid ultrasound whic...

Mrs IP is a 79 year old lady with a past medical history of spleenic marginal zone lymphoma, diagnosed in 2007 and treated with chemotherapy. She has suffered two relapses but despite her diagnosis had remained generally quite fit and healthy until the recent issues. An IgM paraprotein was identified in the patient’s serum an December 2014.In April 2015 Mrs IP presented to her GP complaining of cramping symptoms overnight, especially marked in her h...

A 60-year-old HIV positive man was referred from the genitourinary physicians for investigation of hypercalcaemia (calcium 3.20 mmol/l). He described non-specific symptoms of tiredness and polyuria. Past medical history included well-controlled HIV with an undetectable viral load, secondary syphilis and a history of renal stones. Medications included Didanosine, Emtricitabine, Darunavir and Ritonavir.Initial investigations demonstrated a suppressed parat...

Background and aims: In 2010 pituitary service improvements were instigated, e.g., creation of local pituitary MDTs/joint pituitary clinics with surgeons. In the absence of national guidelines on post-surgical follow up of pituitary patients there was an evolution of local best practice standards. An audit was conducted in March 2015.Methods: Twenty-six patients underwent pituitary surgery at local tertiary centre in 2013/14 with endocrine care based at ...

Objective: We reviewed clinical and biochemical characteristics and post-operative outcomes in patients undergoing surgery for PHA in UHS between January 2014 and June 2022 (8.5-year period).Results: 17 patients (41% female, mean age 45y) underwent adrenalectomy for PHA during this period. 5/17 (29%) required admissions related to PHA, 7/17 had blood pressure (BP) of ≥ 200 mmol/Hg, 11/17 (65%) potassium ≤3 mmol/l, 5/17 required ≥ 4 BP a...

Introduction: Patients with hypopituitarism often report poor quality of life (QoL) despite adequate hormonal replacement therapy. Oxytocin, a peptide hormone produced in the hypothalamus and released by the posterior pituitary, has been known for its role in social and emotional behaviour. Our aim was to investigate the relationship between oxytocin and QoL domains in patients with hypopituitarism under optimal hormonal replacement therapy.<p class="abste...